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Immunogenicity Analysis

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With its many years of experience in applying immunochemical analysis to clinical diagnostics and the research field, Cygnus has assembled a comprehensive menu of reagents and test kits designed to meet the challenges faced by biopharmaceutical companies in development of analytical methods to detect and fully characterize immune responses in patients.

These robust and proven reagents have been developed to overcome many of the non-specific or false positive reactions that often confuse analysis of patient immune responses. Patient antibodies to the therapeutic drug can cause a variety of problems. When patient antibody binds to the drug it may be more rapidly cleared or even neutralized, as has been reported for proteins like insulin, interferon and others to treat hemophilia.

Immunogenicity of the drug gives the potential for significant hypersensitivity reactions and may even progress to the development of auto-antibodies to the patient’s natural version of that protein as has been reported for the recombinant hormone, erythropoietin. Our well characterized immunospecific reagents can be used for the following purposes:

  • To establish baseline or pretherapy immune response.
  • Detect titer increases, post therapy.
  • Screening of patient population to identify those who may have neutralizing antibodies.
  • Establish correlation of antibody titer of patient response to therapy.
  • Epitope mapping of the immunogenic portion of the drug.
  • Distinguish between immunogenicity of the therapeutic drug and the natural form of the protein.
  • Distinguish between an immune response to the drug or to the process contaminants such as host cell proteins.
  • Specific isotyping and subtyping of antibodies involved in the immunogenic response.
Product results: 19
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Catalog # Name Target Species Host Concentration Size Price Qty.
IM151 Anti-Human IgG1:HRP 1 ml $183.75
IM152 Anti-Human IgG2:HRP 1 ml $183.75
IM153 Anti-Human IgG3:HRP 1 ml $183.75
IM154 Anti-Human IgG4:HRP 1 ml $210.00
IM112 BSA Antigen 1 ml $157.50
IM115 CHO-CM HCP Antigen 1 ml $367.50
IM116 E.coli HCP Antigen 1 ml $367.50
IM140 Goat, anti-human IgA 1 ml $210.00
IM141 Goat, anti-human IgD 1 ml $210.00
IM142 Goat, anti-human IgE 1 ml $210.00